Reporter affinity labels: an o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors

J Med Chem. 2000 Jun 29;43(13):2489-92. doi: 10.1021/jm000138s.

Authors

B Le Bourdonnec¹, R El Kouhen, M M Lunzer, P Y Law, H H Loh, P S Portoghese

Affiliation

¹ Department of Medicinal Chemistry, College of Pharmacy, School of Medicine, University of Minnesota, Minneapolis 55455, USA.

PMID: 10891107
DOI: 10.1021/jm000138s

No abstract available

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Affinity Labels
Animals
CHO Cells
Cricetinae
Ligands
Mice
Naltrexone / analogs & derivatives*
Naltrexone / chemical synthesis
Naltrexone / chemistry
Naltrexone / metabolism
Naltrexone / pharmacology
Narcotic Antagonists / chemical synthesis*
Narcotic Antagonists / chemistry
Narcotic Antagonists / metabolism
Narcotic Antagonists / pharmacology
Pain Measurement
Receptors, Opioid / metabolism*
Receptors, Opioid, delta / metabolism
Receptors, Opioid, kappa / metabolism
Receptors, Opioid, mu / metabolism
o-Phthalaldehyde / analogs & derivatives*
o-Phthalaldehyde / chemical synthesis*
o-Phthalaldehyde / chemistry
o-Phthalaldehyde / metabolism

Substances

Affinity Labels
Ligands
Narcotic Antagonists
Receptors, Opioid
Receptors, Opioid, delta
Receptors, Opioid, kappa
Receptors, Opioid, mu
Naltrexone
o-Phthalaldehyde
beta-funaltrexamine